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It is commonly used in food additives 27 , and has also been reported to cause oxidative stress, protein modification, DNA damage, and lysis of stromal cells 28

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Activation of SIRT1 counteracts oxidative-stress-induced damage by inhibiting the mitogen-activated protein kinases (MAPK), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways and may mitigate pathological events in psoriasis