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37 Furthermore, even if CRF application protects against gastric ulcers, 38 exogenous administration of CRF can reproduce cardinal features of diarrhea predominant irritable bowel syndrome including anxiogenic behavior, enhanced visceral pain to colorectal distention, increased colonic mucus secretion, propulsive motility, development of watery stool/diarrhea, and increased colonic mucosal permeability facilitating bacterial translocation into colonic tissue

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Treatment:3 Months

TAAR1 Activation & NET Reverse Mode : Ephedrine directly binds to and stimulates intracellular trace amine-associated receptors (e.g