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Luan et al found endothelial dysfunction in hypertension-associated ED rats, with the increased expression of the NOD-like receptor thermal protein domain associated protein 3 inflammasome, caspase-1, gasdermin-D, and the pro-inflammatory cytokines interleukin-1β and interleukin-18 in the CC, supporting the involvement of pyroptosis in vascular endothelial injury related to hypertension-associated ED [119]