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Targeting NAD(+) Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma [PMID: 31952784] Laboratory literature summary: Targeting NAD(+) Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma

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Blocking NNMT keeps nicotinamide in the NAD+ salvage pathway and S-adenosylmethionine available for polyamine synthesis, and in mouse models of diet-induced obesity that translates into smaller adipocytes, lower adipose mass, better oral glucose tolerance and less hepatic steatosis, with no measurable change in food intake