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The SURMOUNT trial programme documented 20–22% body weight reduction with high-dose Tirzepatide in the obesity indication — exceeding Semaglutide’s 15–17% Wegovy outcomes and establishing Tirzepatide as the highest-efficacy approved pharmacological weight loss treatment, with body weight reductions approaching those historically achievable only through bariatric surgery and generating major EU research activity in the neurobiological mechanisms of dual incretin-driven weight loss

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Tesamorelin trials ran 26 weeks for a reason