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Subchondral bone remodelling further accelerates disease progression through sclerosis, cystic degeneration, and osteophyte formation, which results in altered load distribution and thereby triggers cartilage damage through altered TGF-β and Wnt signalling (Chen et al ., 2017

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Now, a Japanese study has found that a monthly injection of an engineered antibody that targets interleukin-8 (IL-8), an The research, published in Science Translational Medicine , suggests that this might lead to the first disease-modifying therapy for people with endometriosis