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doi: 10.3390/ijms20184659

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Chalmers et al.’s prospective study further confirmed that elevated sputum NE activity correlates closely with increased future acute exacerbation risk, with high sputum NE activity levels effectively predicting patient disease progression and prognosis ( Traditional NSP-targeted therapeutic strategies primarily involve direct inhibition of activated NSPs, such as the NE inhibitor AZD9668 (Stevens et al., 2011)